Recurrent life-threatening bleeding due to acquired clotting factor XIII inhibitor in a Chinese patient with systemic lupus erythematosus
نویسندگان
چکیده
Inhibitor associated clotting factor XIII deficiency is a potentially life-threatening bleeding disorder with normal baseline coagulation studies, and may be associated with various drugs and autoimmune diseases. Failure to recognize this rare condition may lead to catastrophic outcome. We report a 52-year-old male with systemic lupus erythematosus (SLE) presented with recurrent spontaneous haematoma due to acquired inhibitor to clotting factor XIII, resulting in fatal outcome. In this report, we also discuss thoroughly on the biology of factor XIII, clinical features, investigations and management of patients with acquired factor XIII inhibitor.
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